Vancamp P., Spirhanzlova P., Sébillot A., Butruille L., Gothié J.D., Le Mével S., Leemans M., Wejaphikul K., Meima M., Mughal B.B., Roques P., Remaud S., Fini J.B., Demeneix B. (2021) The pyriproxyfen metabolite, 4′–OH–PPF, disrupts thyroid hormone signaling in neural stem cells, modifying neurodevelopmental genes affected by ZIKA virus infection. Environmental Pollution 2021 September 15. doi : 10.1016/j.envpol.2021.117654


Demeneix B., Vandenberg L. N., Ivell R., Zoeller R. T. (2020) Thresholds and endocrine disruptors: An endocrine society policy perspective. Journal of the Endocrine Society 2020 October. doi : 10.1210/jendso/bvaa08.

Vancamp P., Butruille L., Demeneix B., Remaud S. (2020) Thyroid Hormone and Neural Stem Cells: Repair Potential Following Brain and Spinal Cord Injury. Frontiers in Neuroscience 2020 August 26. doi : 10.3389/fnins.2020.00875.

Kassotis C.D., Vanderberg L.N., Demeneix B., Porta M., Slama R., Transande L. (2020) Endocrine-disrupting chemicals: economic, regulatory, and policy implications. Lancet Diabetes and Endocrinology 2020 August. doi : 10.1016/S2213-8587(20)30128-5.

Vancamp P., Demeneix B. (2020) Is the observed decrease in body temperature during industrialization due to thyroid hormone-dependent thermoregulation disruption ? Front. Endocrinol. 2020 July 22. doi :10.3389/fendo.2020.00470.

Demeneix B. (2020) How fossil fuel-derived pesticides and plastics harm health, biodiversity, and the climate. Lancet Diabetes and Endocrinology 2020 June. doi : 10.1016/S2213-8587(20)30116-9.

Lupu D., Andersson P., Bornehag C.G., Demeneix B., Fritsche E., Gennings C., Lichtensteiger W., Leist M., Leonards P.E.G., Ponsonby A.L., Scholze M., Testa G., Tresguerres J.A.F., Westerink R.H.S., Zalc B., Rüegg J. (2020) The ENDpoiNTs Project: novel testing strategies for endocrine disruptors linked to developmental neurotoxicity. Int. J. Mol. Sci. 2020 March 30. doi : 10.3390/ijms21113978.

Krief S., Iglesias-Gonzalez A., Appenzeller B.M.R., Okimat J.P., Fini J.B., Demeneix B., Vaslin-Reimann S., Lardy-Fontan S., Guma N., Spirhanzlova P. (2020) Road impact in a protected area with rich biodiversity: the case of the Sebitoli road in Kibale National Park, Uganda. Environmental Science and Pollution Research 2020 May 13. doi : 10.1007/s11356-020-09098-0.

Vancamp P., Demeneix B., Remaud S. (2020) Monocarboxylate transporter 8 deficiency: delayed or permanent hypomyelination ? Front Endocrinol. 2020 May 13. doi : 10.3389/fendo.2020.00283.

Kortenkamp A., Axelstad M., Baig A.H., Bergman A., Bornehag C.G., Cenijn P., Christiansen S., Demeneix B, et al. (2020) Removing critical gaps in chemical test methods by developing new assays for the identification of thyroid hormone system-disrupting chemicals – The ATHENA Project. Int J Mol Sci. 2020 April 28. doi : 10.3390/ijms21093123.

Demeneix B., Leemans M., Couderq S. (2020) Pyrethroid exposure: not so harmless after all. Lancet Diabetes Endocrinol. 2020 April 8. doi : 10.1016/S2213-8587(20)30039-5.

Muncke J., Andersson A.M., Backhaus T., Boucher J.M., Carney Almroth B., Castillo A., Chevrier J., Demeneix B., Emmanuel J.A., Fini J.B., Gee D., Geueke B., Groh K., Heindel J.J., Houlihan J., Kassotis C.D., Kwiatkowski C.F., Lefferts L.Y., Maffini M.V., Martin O.V., Peterson Myers J., Nadal A., Nerin C., Pelch K.E., Rojello Fernandez S., Sargis R.M., Soto A.M., Trasande L., Vendenberg L.N., Wagner M., Wu C., Zoeller R.T., Scheringer M. (2020) Impacts of food contact chemicals on human health: a consensus statement. Environ Health 2020 March 3. doi : 10.1186/s12940-020-0572-5.

Drakvik E., Altenburger R., Aoki Y., Backhaus T., Bahadori T., Barouki R., Brack W., Cronin M.T.D., Demeneix B., Hougaard Bennekou S., Van Klaveren J., Kneuer C., Kolossa-Gehring M., Lebret E., Posthuma L., Reiber L., Rider C., Rüegg J., Testa G., Van Der Burg B., Van Der Voet H., Warhurst A.M., Van Der Water B., Yamazaki K., Öberg M., Bergman A. (2020) Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment. Environ Int. 2020 January. doi : 10.1016/j.envint.2019.105267.

Gothié J.D., Vancamp P., Demeneix B., Remaud S. (2020) Thyroid hormone regulation of neural stem cell fate: from development to ageing. Acta Physiol (Oxf). 2020 January. doi : 10.1111/apha.13316.


Demeneix B. (2019) Evidence for prenatal exposure to thyroid disruptors and adverse effects on brain development. European Thyroid Journal. 2019 December. doi : 10.1159/000504668.

Vancamp P., Gothié J.D., Luongo C., Sébillot A., Le Blay K., Butruille L., Pagnin M., Richardson S.J., Demeneix B., Remaud S. (2019) Gender-specific effects of transthyretin on neural stem cell fate in the subventricular zone of the adult mouse. Scientific Reports 2019 December 23. doi :10.1038/s41598-019-56156-w.

Terrien J., Seugnet I., Seffou B., J. Herrero M., Bowers J., Chamas L., Decherf S., Duvernois-Berthet E., Djediat C., Ducos B., Demeneix B., Clerget-Froidevaux M.S. (2019) Reduced central and peripheral inflammatory responses and increased mitochondrial activity contribute to diet-induced obesity resistance in WSB/EiJ mice. Scientific Reports 2019 December 23. doi : 10.1038/s41598-019-56051-4.

Leemans M., Couderq S., Demeneix B., Fini J.B. (2019) Pesticides with potential thyroid hormone-disrupting effects: a review of recent data. Front. Endocrinol. 2019 December 9. doi : 10.3389/fendo.2019.00743.

Levie D., Derakhshan A., Shu H., Broeren M., de Poortere R., Peeters R., Bornehag CG.,10, Demeneix B., Korevaar T. (2019) The association of maternal iodine status in early pregnancy with thyroid function in the SELMA study. Thyroid. 2019 Sept 16. doi : 10.1089/thy.2019.0164.

Derakhshan A, Shu H, Peeters RP, Kortenkamp A, Lindh CH, Demeneix B, Bornehag CG, Korevaar TIM. (2019) Association of urinary bisphenols and triclosan with thyroid function during early pregnancy. Environ Int. 2019 Sept 12. ;133(Pt A):105123. doi : 10.1016/j.envint.2019.105123.

Deprouw C., Courties A., Fini J.B., Clerget-Froidevaux M.S., Demeneix B., Berenbaum F., Sellam J., Louati K. (2019) Are pollutanats a new risk factor for osteoarthrtitis ? Results from a systematic litterature review.  Annals of the Rheumatic Diseases. 2019 June. doi: 10.1136/annrheumdis-2019-eular.8175.

Zoeller R.T., Doan L., Demeneix B., Gore A.C., Nadal A., Tan S. (2019) Update on activities in Endocrine Disruptor research and policy. Endocrinology. 2019 May 9. pii: en.2019-00166. doi: 10.1210/en.2019-00166.

Marshall L., Vivien C., Girardot F., Péricard L., Scerbo P., Palmier K., Demeneix B.A., Coen L. (2019) Stage-dependent cardiac regeneration in Xenopus is regulated by thyroid hormone availability. PNAS.  2019 Feb 12. pii: 201803794. doi: 10.1073/pnas.1803794116.

Spirhanzlova P., Fini J.B., Demeneix B., Lardy-Fontan S., Vaslin-Reimann S., Lalere B., Guma N., Tindall A., Krief S. (2019) Composition and endocrine effects of water collected in the Kibale national park in Uganda. Environmental Pollution. 2019 April 14. doi: 10.1016/j.envpol.2019.05.006.


Derakhshan A., Shu, H., Broeren M.A.C., de Poortere R.A., Wikstrom S., Peeters R.P., Demeneix B.A., Bornehag C.G., Korevaar T.I.M (2018) Reference Ranges and Determinants of Thyroid Function During Early Pregnancy: The SELMA Study. J Clin Endocrinol Metab. 2018 Sep 1;103(9):3548-3556. doi: 10.1210/jc.2018-00890.

Marshall L., Girardot F., Demeneix B.A., Coen L. (2018) Is adult cardiac regeneration absent in Xenopus laevis yet present in Xenopus tropicalis? Cell Biosci. 2018 Apr 19;8:31. doi: 10.1186/s13578-018-0231-5. eCollection 2018.

Le Blay K., Préau L., Morvan-Dubois G., Demeneix B.A. (2018) Expression of the inactivating deiodinase, Deiodinase 3, in the pre-metamorphic tadpole retina. PLoS One, 2018 Apr 11;13(4):e0195374. doi: 10.1371/journal.pone.0195374.

Mughal B.B., Fini J.B., Demeneix B.A. (2018) Thyroid disrupting chemicals and brain development: an update. Endocrine Connections,  2018 Apr;7(4):R160-R186. doi: 10.1530/EC-18-0029.

Mughal B.B., Leemans M., Spirhanzlova P., Demeneix B.A., Fini J.B. (2018) Reference gene identification and validation for quantitative real-time PCR studies in developing Xenopus laevis. Scientific Reports, 2018 Jan 11;8(1):496. doi: 10.1038/s41598-017-18684-1.


Mughal B.B., Demeneix B.A. (2017) Flame retardants and increasing risk of thyroid cancer. Nature Rev Endocrinol.  2017 Nov; 13(11):627-628. doi: 10.1038/nrendo.2017.123. Epub 2017 Sep 22.

Marshall L., Girardot F., Demeneix B.A., Coen L. (2017) In Vivo Transfection of Naked DNA into Xenopus Tadpole Tail Muscle. Cold Spring Harb Protoc. 2017 Nov 1;2017(11):pdb.prot099366. doi: 10.1101/pdb.prot099366.

Remaud S., Ortiz F.C., Perret-Jeanneret M., Aigrot M.S., Gothié J.D., Fekete C., Kvárta-Papp Z., Gereben B., Langui D., Lubetzki C., Angulo M.C., Zalc B., Demeneix B.A. (2017) Transient hypothyroidism favors oligodendrocyte generation providing functional remyelination in the adult mouse brain. eLife. 2017 Sep 6 ;6. pii : e29996. doi: 10.7554/eLife.29996.

Gothié J.D., Sébillot A., Luongo C., Legendre M., Nguyen Van C., Le Blay K.,Perret-Jeanneret M., Remaud S., Demeneix B. (2017) Adult neural stem cell fate is determined by thyroid hormone activation of mitochondrial metabolism. Molecular Metabolism. 2017 Aug 19, doi: 10.1016/j.molmet.2017.08.003.

Mannioui A., Vauzanges Q., Fini J.B., Henriet E., Sekizar S., Azoyan L., Thomas J.L., du Pasquier D., Giovannangeli C., Demeneix B.A., Lubetzki C., Zalc B. (2017) The Xenopus tadpole: An in vivo model to screen drugs favoring remyelination. Mult Scler. 2017 Jul 1:1352458517721355. doi : 10.1177/1352458517721355.

Prichystalova R., Fini J.B., Trasande L., Bellanger M., Demeneix B.A., Maxim L. (2017) Comparison of methods for calculating the health costs of endocrine disrupters : a case study on triclosan. Environ Health. 2017 Jun 9 ;16(1):55. doi : 10.1186/s12940-017-0265-x.

Spirhanzlova P., De Groef B., Nicholson F.E., Grommen S.V.H., Marras G., Sébillot A., Demeneix B.A., Pallud-Mothré S., Lemkine G.F., Tindall A.J., Du Pasquier D. (2017) Using short-term bioassays to evaluate the endocrine disrupting capacity of the pesticides linuron and fenoxycarb. Comp Biochem Physiol C Toxicol Pharmacol. 2017 Jun 17. pii : S1532-0456(17)30123-0.

Gothié J.D., Demeneix B.A., Remaud S. (2017) Comparative approaches to understanding thyroid hormone regulation of neurogenesis. Mol Cell Endocrinol. 2017 May 22. doi : 10.1016/j.mce.2017.05.020.

Krief S., Berny P., Gumisiriza F., Gross R., Demeneix B.A., Fini J.B., Chapman C.A., Chapman L.J., Seguya A., Wasswa J. (2017) Agricultural expansion as risk to endangered wildlife: Pesticide exposure in wild chimpanzees and baboons displaying facial dysplasia. Sci Total Environ. 2017 Nov 15 ; 598:647-656. doi : 10.1016/j.scitotenv.2017.04.113.

Mughal B.B., Leemans M., L De Souza E.C., Le Mével S., Spirhanzlova P., Visser T., Fini J.B., Demeneix B.A. (2017) Functional characterisation of Xenopus thyroid hormone transporters mct8 and oatp1c1. Endocrinology, Jun 7. doi: 10.1210/en.2017-00108.

Krief S., Berny P., Gumisiriza R., Gross R., Demeneix B.A., Fini J.B., Chapman C.A., Chapman L.J, Seguya A., Wasswa J. (2017) Agricultural expansion as risk to endangered wildlife: Pesticide exposure in wild chimpanzees and baboons displaying facial dysplasia. Science of The Total Environment, Volume 598, Pages 647–656. doi: 10.1016/j.scitotenv.2017.04.113.

Marshall L., Vivien C., Girardot F., Péricard L., Demeneix B.A., Coen L., Chai N. (2017) Persistent fibrosis, hypertrophy and sarcomere disorganisation after endoscopy-guided heart resection in adult Xenopus. PLoS One, 9;12(3):e0173418. doi: 10.1371/journal.pone.0173418.

Fini J.B., Mughal B.B., Le Mével S., Leemans M., Lettmann M., Spirhanzlova P., Affaticati P., Jenett A., Demeneix B.A. (2017) Human amniotic fluid contaminants alter thyroid hormone signalling and early brain development in Xenopus embryos. Scientific Reports, 7, 43786. doi: 10.1038/srep43786.


Kortenkamp A., Bourguignon J.P., Slama R., Bergman Å., Demeneix B.A., Ivell R., Panzica G., Trasande L., Zoeller R.T. (2016) EU regulation of endocrine disruptors : a missed opportunity. Lancet Diabetes Endocrinol., 4(8):649-50. doi : 10.1016/S2213-8587(16)30151-6. Epub 2016 Jul 1.

Bourguignon J.P., Slama R., Bergman Å., Demeneix B.A., Ivell R., Kortenkamp A., Panzica G., Trasande L., Zoeller R.T.(2016) Science-based regulation of endocrine disrupting chemicals in Europe : which approach ? Lancet Diabetes Endocrinol., pii : S2213-8587(16)30121-8. doi : 10.1016/S2213-8587(16)30121-8.

Holzer G., Morishita Y., Fini J.B., Lorin T.,  Gillet B., Hughes S., Tohmé M., Deléage G., Demeneix B.A, Arvan P., Laudet V. (2016) Thyroglobulin Represents a Novel Molecular Architecture of Vertebrates. J Biol Chem., pii: jbc.M116.719047.

Slama R., Bourguignon J.P., Demeneix B.A., Panzica G., Kortenkamp A., Zoeller T. (2016) Scientific issues relevant to setting regulatory criteria to identify endocrine disrupting substances in the European Union. Environ Health Perspect; doi: 10.1289/EHP217.

Leung A.M., Korevaar T.I., Peeters R.P., Zoeller R.T., Köhrle J., Duntas L.H., Brent G.A., Demeneix B.A. (2016) Exposure to Thyroid-Disrupting Chemicals: A Transatlantic Call for Action. Thyroid, 26(4):479-80. doi: 10.1089/thy.2016.0077. Epub 2016 Mar 16.

Préau L., Le Blay K., Saint Paul E., Morvan-Dubois G., Demeneix B.A. (2016) Differential thyroid hormone sensitivity of fast cycling progenitors in the neurogenic niches of tadpoles and juvenile frogs. Mol Cell Endocrinol., 420:138-51. doi: 10.1016/j.mce.2015.11.026. Epub 2015 Nov 26.

Spirhanzlova P., Leleu M., Sébillot A., Lemkine G.F., Iguchi T., Demeneix B.A., Tindall A.J. (2016) Oestrogen reporter transgenic medaka for non-invasive evaluation of aromatase activity. Comp Biochem Physiol C Toxicol Pharmacol., 179:64-71. doi: 10.1016/j.cbpc.2015.08.011. Epub 2015 Sep 6.


Buisine N., Ruan X., Bilesimo P., Grimaldi A., Alfama G., Ariyaratne P., Mulawadi F., Chen J., Sung W.K., Liu E.T., Demeneix B.A., Ruan Y., Sachs L.M. (2015) Xenopus tropicalis Genome Re-Scaffolding and Re-Annotation Reach the Resolution Required for In Vivo ChIA-PET Analysis. PLoS One, 10(9):e0137526. doi: 10.1371/journal.pone.0137526. eCollection 2015.

Jansen S.W., Akintola A.A., Roelfsema F., van der Spoel E., Cobbaert C.M., Ballieux B.E., Egri P., Kvarta-Papp Z., Gereben B., Fekete C., Slagboom P.E., van der Grond J., Demeneix B.A., Pijl H., Westendorp R.G., van Heemst D. (2015) Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism. Sci Rep., 5:11525. doi: 10.1038/srep11525.

Bellanger M., Demeneix B.A., Grandjean P., Zoeller R.T., Trasande L. (2015) Neurobehavioral deficits, diseases, and associated costs of exposure to endocrine-disrupting chemicals in the European Union. J Clin Endocrinol Metab, 100(4):1256-66. doi: 10.1210/jc.2014-4323. Epub 2015 Mar 5.


Ghaddab-Zroud R., Seugnet I., Steffensen K.R., Demeneix B.A., Clerget-Froidevaux M.S. (2014) Liver X receptor regulation of thyrotropin-releasing hormone transcription in mouse hypothalamus is dependent on thyroid status. PLoS One, 9(9):e106983. doi: 10.1371/journal.pone.0106983.

Pourabdolhossein F., Mozafari S., Morvan-Dubois G., Mirnajafi-Zadeh J., Lopez-Juarez A., Pierre-Simons J., Demeneix B.A., Javan M. (2014) Nogo receptor inhibition enhances functional recovery following lysolecithin-induced demyelination in mouse optic chiasm. PLoS One, 9(9):e106378. doi: 10.1371/journal.pone.0106378. eCollection 2014.

Sébillot A., Damdimopoulou P., Ogino Y., Spirhanzlova P., Miyagawa S., Du Pasquier D., Mouatassim N., Iguchi T., Lemkine G.F., Demeneix B.A., Tindall A.J. (2014) Rapid fluorescent detection of (anti)androgens with spiggin-gfp medaka.  Environ Sci Technol., 48(18):10919-28. doi: 10.1021/es5030977. Epub 2014 Aug 29.

Préau L., Fini J.B., Morvan-Dubois G., Demeneix B.A. (2014) Thyroid hormone signaling during early neurogenesis and its significance as a vulnerable window for endocrine disruption. Biochim Biophys Acta, pii: S1874-9399(14)00167-9. doi: 10.1016/j.bbagrm.2014.06.015. Epub 2014 Jun 27.

Remaud S., Gothié J.D., Morvan-Dubois G., Demeneix B.A. (2014) Thyroid hormone signaling and adult neurogenesis in mammals. Front Endocrinol (Lausanne), 5:62. doi: 10.3389/fendo.2014.00062. eCollection 2014. Review.

Guissouma H., Ghaddab-Zroud R., Seugnet I., Decherf S., Demeneix B.A., Clerget-Froidevaux M.S. (2014) TR alpha 2 exerts dominant negative effects on hypothalamic Trh transcription in vivo. PLoS One, 9(4):e95064. doi: 10.1371/journal.pone.0095064. eCollection 2014.

Scerbo P., Markov G.V., Vivien C., Kodjabachian L., Demeneix B.A., Coen L., Girardot F. (2014) On the origin and evolutionary history of NANOG. PLoS One, 9(1):e85104. doi: 10.1371/journal.pone.0085104. eCollection 2014.


Decherf S., Seugnet I., Becker N., Demeneix B.A., Clerget-Froidevaux M.S. (2013) Retinoic X receptor subtypes exert differential effects on the regulation of Trh transcription. Mol Cell Endocrinol.,381(1-2):115-23. doi: 10.1016/j.mce.2013.07.016. Epub 2013 Jul 26.

Castillo L., Seriki K., Mateos S., Loire N., Guédon N., Lemkine G.F., Demeneix B.A., Tindall A.J. (2013) In vivo endocrine disruption assessment of wastewater treatment plant effluents with small organisms. Water Sci Technol., 68(1):261-8. doi: 10.2166/wst.2013.179.

Bowers J., Terrien J., Clerget-Froidevaux M.S., Gothié J.D., Rozing M.P., Westendorp R.G., van Heemst D., Demeneix B.A. (2013) Thyroid hormone signaling and homeostasis during aging. Endocr Rev., 34(4):556-89. doi: 10.1210/er.2012-1056. Epub 2013 May 21. Review.

Remaud S., López-Juárez S.A., Bolcato-Bellemin A.L., Neuberg P., Stock F., Bonnet M.E., Ghaddab R., Clerget-Froidevaux M.S., Pierre-Simons J., Erbacher P., Demeneix B.A., Morvan-Dubois G. (2013) Inhibition of Sox2 Expression in the Adult Neural Stem Cell Niche In Vivo by Monocationic-based siRNA Delivery. Mol Ther Nucleic Acids, 2:e89. doi: 10.1038/mtna.2013.8.

Punzon I., Latapie V., Le Mével S., Hagneau A., Jolivet P., Palmier K., Fini J.B., Demeneix B.A. (2013) Towards a humanized PPARγ reporter system for in vivo screening of obesogens. Mol Cell Endocrinol, 374(1-2):1-9. doi: 10.1016/j.mce.2013.04.004. Epub 2013 Apr 16.

Morvan-Dubois G., Fini J.B., Demeneix B.A. (2013) Is thyroid hormone signaling relevant for vertebrate embryogenesis? Curr Top Dev Biol., 103:365-96. doi: 10.1016/B978-0-12-385979-2.00013-7. Review.


Remaud S., Morvan-Dubois G., Demeneix B.A. (2012) Thyroid hormone signalling favors neural stem cell commitment. Med Sci (Paris), 28(12):1050-2. doi: 10.1051/medsci/20122812010. Epub 2012 Dec 21.

Scholz S., Renner P., Belanger S.E., Busquet F., Davi R., Demeneix B.A., Denny J.S., Léonard M., McMaster M.E., Villeneuve D.L., Embry M.R. (2013) Alternatives to in vivo tests to detect endocrine disrupting chemicals (EDCs) in fish and amphibians–screening for estrogen, androgen and thyroid hormone disruption. Crit Rev Toxicol., 43(1):45-72. doi: 10.3109/10408444.2012.737762. Epub 2012 Nov 28. Review.

Kouidhi S., Berhouma R., Ammar M., Rouissi K., Jarboui S., Clerget-Froidevaux M.S., Seugnet I., Abid H., Bchir F., Demeneix B., Guissouma H., Elgaaied A.B. (2013) Relationship of thyroid function with obesity and type 2 diabetes in euthyroid Tunisian subjects. Endocr Res., 38(1):15-23. doi: 10.3109/07435800.2012.699987. Epub 2012 Jun 29.

Kouidhi S., Berrhouma R., Rouissi K., Jarboui S., Clerget-Froidevaux M.S., Seugnet I., Bchir F., Demeneix B.A., Guissouma H., Elgaaied A.B. (2013) Human subcutaneous adipose tissue Glut 4 mRNA expression in obesity and type 2 diabetes. Acta Diabetol., 50(2):227-32. doi: 10.1007/s00592-011-0295-8. Epub 2011 May 22.

Kaya F., Mannioui A., Chesneau A., Sekizar S., Maillard E., Ballagny C., Houel-Renault L., Dupasquier D., Bronchain O., Holtzmann I., Desmazieres A., Thomas J.L., Demeneix B.A., Brophy P.J., Zalc B., Mazabraud A. (2012) Live imaging of targeted cell ablation in Xenopus: a new model to study demyelination and repair.  J Neurosci., 32(37):12885-95.

Fini J.B., Le Mével S., Palmier K., Darras V.M., Punzon I., Richardson S.J., Clerget-Froidevaux M.S., Demeneix B.A. (2012) Thyroid hormone signaling in the Xenopus laevis embryo is functional and susceptible to endocrine disruption. Endocrinology, 153(10):5068-81. Epub 2012 Sep 11.

Fini J.B., Riu A., Debrauwer L., Hillenweck A., Le Mével S., Chevolleau S., Boulahtouf A., Palmier K., Balaguer P., Cravedi J.P., Demeneix B.A., Zalko D. (2012) Parallel biotransformation of tetrabromobisphenol A in Xenopus laevis and mammals: Xenopus as a model for endocrine perturbation studies. Toxicol Sci., 125(2):359-67.

Vivien C., Scerbo P., Girardot F., Le Blay K., Demeneix B.A., Coen L. (2012) Non-viral expression of mouse Oct4, Sox2, and Klf4 transcription factors efficiently reprograms tadpole muscle fibers in vivo. J Biol Chem, 287(10):7427-35.

Lopez-Juarez A., Remaud S., Hassani Z., Jolivet P., Pierre Simons J., Sontag T., Yoshikawa K., Price J., Morvan-Dubois G., Demeneix B.A. (2012) Thyroid hormone signaling acts as a neurogenic switch by repressing Sox2 in the adult neural stem cell niche. Cell Stem Cell, 10(5):531-43.

Scerbo P., Girardot F., Vivien C., Markov G.V., Luxardi G., Demeneix B.A., Kodjabachian L., Coen L. (2012) VentX factors function as Nanog-like guardians of developmental potential in Xenopus. PLoS One, 7(5):e36855.


Decherf S., Demeneix B.A. (2011) The obesogen hypothesis: a shift of focus from the periphery to the hypothalamus. J Toxicol Environ Health B Crit Rev., 14(5-7):423-48.

Terrien X., Fini J.B., Demeneix B.A., Schramm K.W, Prunet P.(2011) Generation of fluorescent zebrafish to study endocrine disruption and potential crosstalk between thyroid hormone and corticosteroids. Aquat Toxicol., 105(1-2):13-20.

Bilesimo P., Jolivet P., Alfama G., Buisine N., Le Mével S., Havis E., Demeneix B.A., Sachs LM. (2011) Specific histone lysine 4 methylation patterns define TR-binding capacity and differentiate direct T3 responses. Mol Endocrinol., 25(2):225-37.

Gibert Y., Sassi-Messai S., Fini J.B., Bernard L., Zalko D., Cravedi J.P., Balaguer P., Andersson-Lendahl M., Demeneix B.A., Laudet V. (2011) Bisphenol A induces otolith malformations during vertebrate embryogenesis. BMC Dev Biol., 11:4.

Kouidhi S., Jarboui S., Marrakchi R., Clerget Froidevaux M.S., Seugnet I., Abid H., Bchir F., Brahem M., Demeneix B.A., Guissouma H., Elgaaied A.B. (2011) Adiponectin expression and metabolic markers in obesity and type 2 diabetes. J Endocrinol Invest, 34(2):e16-23. doi: 10.3275/7204. Epub 2010 Jul 22.


Decherf S., Seugnet I., Kouidhi S., Lopez-Juarez A., Clerget-Froidevaux M.S., Demeneix B.A. (2010) Thyroid hormone exerts negative feedback on hypothalamic type 4 melanocortin receptor expression. Proc Natl Acad Sci U S A., 107(9):4471-6. Epub 2010 Feb 16.

Decherf S., Seugnet I., Fini J.B., Clerget-Froidevaux M.S., Demeneix B.A. (2010) Disruption of thyroid hormone-dependent hypothalamic set-points by environmental contaminants. Mol Cell Endocrinol., 323(2):172-82. Epub 2010 Apr 24.

Kouidhi S., Jarboui S., Clerget Froidevaux M.S., Abid H., Demeneix B.A, Zaouche A., Benammar Elgaaied A., Guissouma H. (2010) Relationship between subcutaneous adipose tissue expression of leptin and obesity in Tunisian patients. Tunis Med., 88(8):569-72.


Fini J.B., Dolo L., Cravedi J.P., Demeneix B.A., Zalko D. (2009) Metabolism of the endocrine disruptor BPA by Xenopus laevis tadpoles. Ann N Y Acad Sci., 1163:394-7.

Markov G.V., Tavares R., Dauphin-Villemant C., Demeneix B.A., Baker M.E., Laudet V. (2009) Independent elaboration of steroid hormone signaling pathways in metazoans. Proc Natl Acad Sci USA, 106(29):11913-8. Epub 2009 Jul 1.

Bondesson M., Jönsson J., Pongratz I., Olea N., Cravedi J.P., Zalko D., Håkansson H., Halldin K., Di Lorenzo D., Behl C., Manthey D., Balaguer P., Demeneix B., Fini J.B., Laudet V., Gustafsson J.A. (2009) A CASCADE of effects of bisphenol A. Reprod Toxicol., 28(4):563-7. Epub 2009 Jul 3.

Kouidhi S, Seugnet I, Decherf S, Guissouma H, Elgaaied AB, Demeneix B, Clerget-Froidevaux MS. Peroxisome proliferator-activated receptor-gamma (PPARgamma) modulates hypothalamic Trh regulation in vivo. Mol Cell Endocrinol. 2010 Apr 12;317(1-2):44-52. Epub 2009 Nov 10.

Fini J.B., Pallud-Mothré S., Le Mével S., Palmier K., Havens C.M., Le Brun M., Mataix V., Lemkine G.F., Demeneix B.A., Turque N., Johnson P.E. (2009) An innovative continuous flow system for monitoring heavy metal pollution in water using transgenic Xenopus laevis tadpoles. Environ Sci Technol, 43(23):8895-900.


Havis E., Bilesimo P., Demeneix B.A., Sachs L.M. (2008) Mechanisms underlying thyroid hormone response gene regulation during amphibian development. J Soc Biol., 202(2):73-81.

Morvan-Dubois G., Demeneix B.A., Sachs L.M. (2008) Xenopus laevis as a model for studying thyroid hormone signalling: from development to metamorphosis. Mol Cell Endocrinol, 293(1-2):71-9. Epub 2008 Jun 28. Review.

Decherf S., Hassani Z., Demeneix B.A. (2008) In vivo siRNA delivery to the mouse hypothalamus shows a role of the co-chaperone XAP2 in regulating TRH transcription. Methods Mol Biol., 433:355-66.

Demeneix B.A., Richardson S.J. (2008) Editorial foreword to MCE special issue on “non-mammalian models of endocrine signalling”. Mol Cell Endocrinol., 293(1-2):1. Epub 2008 Aug 5.

Markov G., Lecointre G., Demeneix B.A., Laudet V. (2008) The “street light syndrome”, or how protein taxonomy can bias experimental manipulations. Bioessays, 30(4):349-57.

Bagamasbad P., Howdeshell K.L., Sachs L.M., Demeneix B.A., Denver R.J. (2008) A Role For Basic Transcription Element-Binding Protein 1 (Bteb1) In The Autoinduction Of Thyroid Hormone Receptor. J Biol Chem., 283(4):2275-2285.


Fierro A.C., Thuret R., Coen L., Perron M., Demeneix B.A., Wegnez M., Gyapay G., Weissenbach J., Wincker P., Mazabraud A., Pollet N. (2007) Exploring Nervous System Transcriptomes During Embryogenesis And Metamorphosis In Xenopus Tropicalis Using Est Analysis. Bmc Genomics, 8:118.

Richardson S.J., Lemkine G.F., Alfama G., Hassani .Z, Demeneix B.A. (2007) Cell Division And Apoptosis In The Adult Neural Stem Cell Niche Are Differentially Affected In Transthyretin Null Mice. Neurosci Lett., 421(3):234-8. Epub 2007 Jun 2.

Fini J.B., Le Mével S., Turque N., Palmier K., Zalko D., Cravedi J.P. and Demeneix B.A. (2007) An In Vivo Multiwell-Based Fluorescent Screen For Monitoring Vertebrate Thyroid Hormone Disruption.  Environmental Science And Technology, 41(16):5908-14.

Hassani z., François J.C., Alfama G., Morvan G., Paris M., Giovannangeli C. & Demeneix B.A. (2007) A Hybrid Cmv-H1 Promoter Improves Efficiency Of Pei-Delivered Shrna In The Mouse Brain. Nucleic Acid Research, 35(9):E65.

Coen L., Le Blay K., Rowe I. & Demeneix B.A. (2007) Caspase-9 Regulates Apoptosis/Proliferation Balance During Metamorphic Brain Remodeling In Xenopus. Proc Natl Acad Sci U S A., 104(20):8502-7.

Du Pasquier D., Chesneau A., Ymlahi-Ouazzani Q., Boistel R., Pollet N., Ballagny C., Sachs L.M., Demeneix B.A. And Mazabraud A. (2007) Tbid Mediated Activation Of The Mitochondrial Death Pathway Leads To Genetic Ablation Of The Lens In Xenopus Laevis. Genesis, 45 : 1-10.


Kuiper G.G., Klootwijk W., Morvan Dubois G., Destree O., Darras V.M., Van Der Geyten S., Demeneix B.A., Visser T.J. (2006) Characterization Of Recombinant Xenopus Laevis Type I Iodothyronine Deiodinase: Substitution Of A Proline Residue In The Catalytic Center By Serine (Pro132ser) Restores Sensitivity To 6-Propyl-2-Thiouracil. Endocrinology, 147(7):3519-29.

Nygard M., Becker N., Demeneix B.A., Pettersson K., Bondesson M.  (2006) Thyroid Hormone-Mediated Negative Transcriptional Regulation Of Necdin Expression. J Mol Endocrinol., 36(3):517-30.

Sinzelle L., Vallin J., Coen L., Chesneau A., Du Pasquier D., Pollet N., Demeneix B.A., Mazabraud A. (2006) Generation Of Trangenic Xenopus Laevis Using The Sleeping Beauty Transposon System. Transgenic Res., 15(6):751-60.

Chai N., Deforges L., Sougakoff W., Truffot-Pernot C., De Luze A., Demeneix B.A., Clement M., Bomsel M.C. (2006) Mycobacterium Szulgai Infection In A Captive Population Of African Clawed Frogs (Xenopus Tropicalis). J Zoo Wildl Med., 37(1):55-8.

Safi R., Vlaeminck-Guillem V., Duffraisse M., Seugnet I., Plateroti M., Margotat A., Duterque-Coquillaud M.,  Crespi E.J., Denver R.J., Demeneix B.A., Laudet V. (2006) Pedomorphosis Revisited: Thyroid Hormone Receptors Are Functional In Necturus Maculosus. Evol Dev., 8(3):284-292.

Morvan Dubois G., Sebillot A., Kuiper G.G., Verhoelst C.H., Darras V.M., Visser T.J., Demeneix B.A. (2006) Deiodinase Activity Is Present In Xenopus Laevis During Early Embryogenesis. Endocrinology, 147(10):4941-9.

Havis E., Le Mével S., Morvan-Dubois G., Shi D.L., Scanlan T.S., Demeneix B.A. And Sachs L.M. (2006) Unliganded Thyroid Hormone Receptor Is Essential For Xenopus Laevis Eye Development. Embo J., 20 : 4943-4951.

Guissouma H., Froidevaux M.S., Hassani Z., Demeneix B.A. (2006) In Vivo Sirna Delivery To The Mouse Hypothalamus Confirms Distinct Roles Of Tr Beta Isoforms In Regulating Trh Transcription. Neurosci Lett., 406(3):240-3.

Clerget-Froidevaux M.S., Berg P., Seugnet I., Decherf S., Becker N., Sachs L.M., Bilesimo P., Nygard  M., Pongratz I. And Demeneix B.A. (2006) The Co-Chaperone Xap2 Is Required For Activation Of Hypothalamic Trh Transcription In Vivo. Embo Rep., 7 : 1035-1039.

Kuiper G.G., Klootwijk W., Morvan Dubois G., Destree O., Darras V.M., Van der Geyten S., Demeneix B.A., Visser T.J. (2006) Characterization of recombinant Xenopus laevis type I iodothyronine deiodinase: substitution of a proline residue in the catalytic center by serine (Pro132Ser) restores sensitivity to 6-propyl-2-thiouracil. Endocrinology, 147(7):3519-29.

Safi R., Vlaeminck-Guillem V., Duffraisse M., Seugnet I., Plateroti M., Margotat A., Duterque-Coquillaud M., Crespi E.J., Denver R.J., Demeneix B.A., Laudet V. (2006) Pedomorphosis revisited: thyroid hormone receptors are functional in Necturus maculosus. Evol Dev., 8(3):284-92.

Nygard M., Becker N., Demeneix B.A., Pettersson K., Bondesson M. (2006) Thyroid hormone-mediated negative transcriptional regulation of Necdin expression. J Mol Endocrinol., 36(3):517-30.

Du Pasquier D., Rincheval V., Sinzelle L., Chesneau A., Ballagny C., Sachs L.M., Demeneix B.A., Mazabraud A. (2006) Developmental cell death during Xenopus metamorphosis involves BID cleavage and caspase 2 and 8 activation. Dev Dyn, 235(8):2083-94.

Dif F., Djediat C., Alegria O., Demeneix B.A., Levi G. (2006) Transfection of multiple pulmonary cell types following intravenous injection of PEI-DNA in normal and CFTR mutant mice. J Gene Med., 8 : 82-89.


Turque N., Palmier K., Le Mével S., Alliot C., Demeneix B.A. (2005) A rapid, physiologic protocol for testing transcriptional effects of thyroid-disrupting agents in premetamorphic Xenopus tadpoles. Environ Health Perspect, 113(11):1588-93.

Demeneix B.A., Behr J.P. (2005) Polyethylenimine (PEI). Adv Genet., 53PA:215-230.

Rowe I., Le Blay K., Du Pasquier D., Palmier K., Levi G., Demeneix B.A., Coen L. (2005) Apoptosis of tail muscle during amphibian metamorphosis involves a caspase 9-dependent mechanism. Dev Dyn, 233(1):76-87.

Lemkine G.F., Raji A., Alfama G., Turque N., Hassani Z., Alegria-Prevot O., Samarut J., Levi G., Demeneix B.A. (2005) Adult neural stem cell cycling in vivo requires thyroid hormone and its alpha receptor. FASEB J., 19(7):863-5.

Trudeau V.L., Turque N., Le Mével S., Alliot C., Gallant N., Coen L., Pakdel F., and Demeneix B.A. (2005) Assessment of estrogenic endocrine disrupting chemical actions in the brain using in vivo somatic gene transfer.  Environ Health Perspectives 113(3):329-34.

Hassani Z., Lemkine G.F., Erbacher P., Alfama G., Palmier K., Giovannangeli C., Behr J.P. & Demeneix B.A. (2005) Lipid-mediated siRNA delivery down regulates exogenous gene expression in the mouse brain at picomolar levels. J. Gene Medecine, 7(2):198-207.


Clerget-Froidevaux M.S., Seugnet I. and Demeneix B.A. (2004) Thyroid status co-regulates thyroid hormone receptor and co-modulator genes specifically in the hypothalamus. FEBS Letters, 569:341-5.

Sachs L., Le mével S., Demeneix B.A. (2004) Implication of bax in Xenopus laevis tail regression at metamorphosis. Developmental Dynamics, 231:671-682.

Dupré S.M., Guissouma H., Flamant F., Seugnet I., Scanlan T.S., Baxter J.D., Samarut J., Demeneix B.A., Becker N. (2004) Both TRbeta1 and TRbeta2 contribute to regulation of hypothalamic TRH. Endocrinology, 45:2337-45.

Safi R., Bertrand S., Marchand O., Duffraisse M., De Luze A., Vanacker J.M., Maraninchi M., Margotat A., Demeneix B.A., Laudet V. (2004) The axolotl (Ambystoma mexicanum), a neotenic amphibian, expresses functional thyroid hormone receptors. Endocrinology, 145(2):760-72.


Havis E., Sachs L., Demeneix B.A. (2003) Metamorphic genes have specific co-regulator requirements. EMBO Reports, 4:883-8.


Sachs L., Jones P.L., Havis E., Rouse N., Demeneix, B.A. and Shi Y.B. (2002) N-CoR recruitment by unliganded thyroid hormone receptor in gene repression during Xenopus laevis development. Mol. Cell Biol., 22(24):8527-38.

Rowe I., ,Coen L.,  Le Blay K., Le Mével S., Demeneix B.A. (2002) Autonomous regulation of muscle fibre fate during metamorphosis in Xenopus tropicalis. Developmental dynamics, 224, 381-390.

Kissa K., Mordelet E., Soudais C., Demeneix B.A., Brulet P. & Coen L. (2002) In vivo neuronal tracing with GFP-TTC gene delivery. Mol. Cell. Neurosci., 20:627- 637.

Guissouma H., Dupre S.M., Becker N., Jeannin E., Seugnet I., Devergne B. & Demeneix B.A. (2002) Feedback on hypothalamic thyrotropin-releasing hormone transcription is dependent on thyroid hormone receptor N-terminus. Mol. Endocrinology, 16:1652-1666.

Lemkine G., Mantero S., Migné C., Raji A., Goula D., Normandie P., Levi G. & Demeneix B.A. (2002) Preferential transfection of adult mouse neural stem cells and their immediate progeny in vivo with polyethylenimine. Mol. Cell. Neurosci., 19: 165-174.


Dif F., Saunier F., Demeneix B.A., Kelly P.A. & Edery M. (2001) Cytokine-Inducible SH2-Containing Protein (CIS) suppresses prolactin signaling by binding the PRL receptor. Endocrinology, 142: 5286-93.

Becker N., Seugnet I., Guissouma H., Dupre S.M. & Demeneix B.A. (2001) NCoR and SMRT corepressor expression is incompatible with T3-dependent Thyrotropin Releasing Hormone regulation. Endocrinology, 142:5321-31.

Coen L., du Pasquier D., Le Mevel S., Brown S., Tata J., Mazabraud A. & Demeneix B.A. (2001) Xenopus Bcl-XL selectively protects Rohon-Beard neurons from Metamorphic Degeneration. Proc Natl Acad Sci USA, 98 7649-8158.

Lemkine G. and Demeneix B.A. (2001) Polyethylenimines for in vivo gene delivery. Curr. Opin. Mol. Therap. 3, 4pp.


Hadj-Sahroui N., Seugnet I., Ghorbel M. and Demeneix B.A. (2000) Hypothyroidism prolongs mitotic activity in the post-natal mouse brain. Neurosci. Lett. 231, 127-130.

Guissouma H., Becker N., Seugnet I., Demeneix B.A. (2000) Transcriptional repression of TRH promoter function by T3: analysis by in vivo gene transfer.  Biochem Cell Biol. 78 :155-63.

Favre-Young H., Dif F., Roussille F., Demeneix B.A., Kelly P.A., Edery M., de Luze A. (2000) Cross-talk between signal transducer and activator of transcription (Stat5) and thyroid hormone receptor-beta 1 (TRbeta1) signaling pathways. Mol Endocrinol. 14:1411-24.

Fabre V., Boutrel B., Hanoun N., Lanfumey L., Fattaccini C.M., Demeneix B., Hamon M., Martres MP. (2000) Homeostatic regulation of serotonergic function by the serotonin transporter as revealed by non-viral gene transfer.  J. Neuroscience 20 : 5065-75.

Almeida OFX.,  Conde G., Crochemore C. Demeneix B.A. Fischer D., Hassan A., Meyer M., Holsboer F., Michaelidis T. (2000) Subtle shifts in the ratio between pro- and anti-apoptotic molecules following activation of corticosteroid receptors determine neuronal apoptosis rate. FASEB. J. 14 : 779-90.

Goula D., Becker N., Lemkine G., Normandie P., Rodrigues J., Mantero S., Levi G., Demeneix B.A. (2000) Rapid crossing of the pulmonary endothelial barrier by polyethylenimine /DNA complexes. Gene Therapy, 7 : 499-504.


Lemkine G., Goula D.,Becker N., Paleari, L. Levi G., Demeneix B.A. (1999) Optimisation of polyethylenimine based gene delivery to mouse brain.  J. Drug Targ., 7 : 305-312.

Coen L., Kissa C., Le Mevel  S., Brulet P. & Demeneix B.A. (1999) A somatic gene transfer approach using recombinat fusion proteins to map muscle-motoneuron projections in Xenopus spinal cord. Int. J.Dev. Biol., 43 : 823 830.

Demeneix B.A., Ghorbel M., Goula  D. (1999) Optimizing Polyethylenimine -based gene deliver to the CNS for analysing promoter analysis and protein function. Methods in Molecular Biology, 133: 12pp.

Ghorbel M.T., Tomilko P. Seugnet I., Hadj- Sahroui N., Levi G., Demeneix B.A. (1999) Thyroid hormone regulation of Krox-24 transcription in the post-natal mouse brain is developmentally regulated but not correlated with mitosis. Oncogene, 18, 917-924.


Ouatas T., Le Mevel S., Demeneix B.A., De Luze A. (1998) T3 dependent physiological regulation of transcription in the Xenopus tadpole brain.  Int. J. Dev. Biol., 42, 1159-1165

Martres M.P.,  Demeneix B.A, Hanoun N., Hamon, M., Giros B. (1998)  Up and down regulation of the dopamine transporter by plasmid DNA transfer in the rat brain  Eur J. Neurosci., 10, 3607-3616.

Guisssouma H., Ghorbel M.T., Seugnet I., Ouatas T. Demeneix B.A. (1998) Physiological regulation of hypothalamic TRH transcription in vivo is T3 receptor isoform-specific.  FASEB J., 12, 1755-1764.

Goula  D.,  Benoist C., Montero S., Merlot G., Levi G., Demeneix B.A. (1998) Polyethylenimine-based intravenous delivery of transgenes to mouse lung alveolar cells. Gene Therapy, 5: 1291-1295.

Goula  D. , Remy J.S., Erbacher P., Wasowizc M., Levi  G., Abdallah  B., Demeneix B.A. (1998) Size diffusibilty and transfection performance of linear PEI/DNA complexes in the mouse central system  Gene Therapy, 5: 712-717.

Behr J.P., Demeneix B.A. (1998) Gene delivery with polycationic amphiphiles and polymers. Current Research in Molecular Therapeutics, 1, 5-12.

Sachs L.M., de Luze A., Demeneix B.A. (1998) Studying amphibian metamorphosis by in vivo gene transfer. Ann. N.Y. Acad. Sci., 839, 152-156.

Abdallah B., Goula D., Ghorbel  M., Guissouma H., Benoist C., Seugnet  I.,  Demeneix B.A. (1998) Non-viral gene transfer for studying signalling in comparative developmental biology’. Ann. N.Y. Acad. Sci., 839, 87-92.


Ghorbel M.,  Seugnet I., Ableitner A.M., Hassan  A. and  Demeneix B.A. (1997) T3 increases mitosis, then bax expression and apoptosis in the optic lobe of the chick embryo. Neurosci. Lett., 231, 127-130.

Sachs L., Abdallah B., Hassan A., Levi G., de Luze A., Reed J., Demeneix B.A. (1997) Apoptosis in Xenopus tadpole tail muscles involves Bax dependent pathways.  FASEB J., 11: 801-808.

Sachs L., Lebrun J.J., De Luze A., Kelly P.A., Demeneix B.A. (1997) Tail regression, apoptosis and thyroid hormone regulation of myosin heavy chain isofroms in Xenopus tadpoles. Mol. Cell. Endoc., 131, 211-219.

Meunier-Durmont C., Grimal H., Sachs L., Demeneix B.A., Forrest C. (1997) Adenovirus enhancement of polyethylenimine-mediated transfer of regulated genes in differentiated cells. Gene Therapy, 4, 808- 814.


Abdallah B., Hassan A., Benoist C., Goula D, Behr J.P., Demeneix B.A. (1996) A powerful non-viral vector for in vivo gene-transfer in the adult mammalian brain: polyethylenimine.Human Gene Therapy, 7, 1947-1954.

Sachs L., de Luze A., Lebrun J.J., Kelly P., Demeneix B.A. (1996) Use of Heterologous DNA Based gene transfer to follow physiological T3-dependent regulation of myosin heavy chain genes in Xenopus tadpoles. Endocrinology, 137, 2191-2194.

Abdallah B., Sachs L., Houdry J., Wegnez M., Demeneix B.A., Mazabraud A. (1996) Thyroid hormone regulation of germ cell-specific EF-1a expression during metamorphosis of Xenopus laevis. Int. J. Dev. Biol., 40: 507-514

Schwartz B., Benoist C., Abdallah  B., Scherman D., Behr J.P., Demeneix B.A. (1996) Gene transfer by naked DNA into adult mouse brain. Gene Therapy, 3, 405-411

Barthel F., Demeneix B.A., Feltz P., Loeffler J.P. (1996) GABAb receptors negatively regulate transcription in cerbellar granular neurons through CREB-dependent mechanisms. Neuroscience, 70, 417-427.


Schwartz B., Benoist C., Scherman D., Behr J.P., Demeneix B.A. (1995) Lipospermine-based gene transfer into the newborn mouse brain is optimized by a low lipospermine/DNA charge ratio. Human Gene Therapy, 6, 1515-1524.

Boussif O., Lezoualc’h F., Zanta  M.,  Mergny M., Scherman D., Demeneix B.A., Behr J.P.  (1995) A novel, versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc. Natl. Acad. Sci. USA, 92, 7297-7303.


Lezoualc’h F., Hassan A.H., Abdel Tawab H., Puymirat J., Demeneix B.A. (1994) Precocious auto-induction of thyroid hormone receptors in chick embryonic hypothalamic neurons. Neuroscience Lett., 180, 197-202.

Flamant F., Demeneix B.A., Benoist C., Markossian-Belin S., Samarut J. (1994) Virofection: a new procedure to achieve stable expression of genes transferred into early embryos. Int J. Dev. Biol., 38, 751-757.

Demeneix B.A., Abdel-Tawab H., Benoist C., Seugnet I., Behr J.P. (1994) Spatial and temporal expression of lipospermine compacted genes transferred into chick embryos in vivo. Biotechniques, 16, 496-501.


De Luze A., Sachs L., Demeneix B.A. (1993) Thyroid hormone dependent transcriptional regulation of exogenous genes transferred into Xenopus tadpole muscle in vivo. Proc. Natl. Acad. Sci. USA, 90, 7322-7326.

Davis H.L., Michel M.L., Mancini M., Jasmin B.J., Demeneix B.A., Klamut H., Quantin  B., Coulomb E.J., whalen R.G. (1993) Direct gene transfer in skeletal muscle : application to gene therapy and genetic vaccination. Acta Cardiologica, 5, 173-179.

Davis H.L., Demeneix B.A., Quantin B., Coulomb E. J., Whalen R.G. (1993) Plasmid DNA is superior to viral vectors for direct gene transfer in a dult mouse skeletal muscle. Human Gene Therapy, 4, 733-740.

Davis H.L., Whalen R.G., Demeneix B.A. (1993) Direct gene transfer into skeletal muscle in vivo: factors affecting efficiency of transfer and stability of expression. Human Gene Therapy, 4, 151-159.

Daugeras-Bernard N., Demeneix B.A., Lachiver F. (1993) Excess iodide and thyroid function in developing chick embryos. Gen. Comp. Endoc., 89, 91-100.


Lezoualc’h F., Hassan A., Loeffler J.P., Lee S.L., Giraud P., Demeneix B.A. (1992) Assignment of the ß thyroid hormone receptor to T3 – dependent inhibition of TRH transcription in hypothalamic neurons. Molecular  Endocrinology, 6, 1797-1804.

Boutillier A.L., Barthel F., Hassan A., Loeffler J.P., Demeneix B.A. (1992) Gene transfer into neurons and chromaffin cells.  Prog. Psycho. Pharm. Biol. Psych., 16, 959-968.

Barthel F., Boutillier A.L., Giraud P., Demeneix B.A., Behr J.P.,  Loeffler J.P. (1992) Gene regulation analysis by lipopolyamine-mediated gene transfer in primary neurons. Methods in Neuroscience, 9, 291-312.


Demeneix B.A., Fredriksson G., Lezoualc’h F., Daugeras-Bernard N., Behr J.P., Loeffler J.P. (1991) Gene transfer into intact vertebrate embryos. Int. J. Dev. Biol., 35, 481-484.

Demeneix B.A., Lezoualc’h F., Hassan A. Loeffler J.P., Giraud P. (1991) Role of beta thyroid hormone receptor in the modulation of TRH. CR Seances Soc Biol, 185, 491-499.


Demeneix B.A., Kley N., Loeffler J.P. (1990) Differentiation to a neuronal phenotype in bovine chromaffin cells is repressed by protein kinase C and is not dependant on c-fos oncopoteins. DNA Cell Biol., 9, 353-345.


Behr J.P., Demeneix B.A., Loeffler J.P., Perez-Mutul J. (1989) Efficient gene transfer into mammalian primary endocrine cells with lipoluamine-coated DNA. Proc. Natl Acad. Sci. USA, 86, 6982-6986.

Trouslard J., Demeneix B.A., Feltz P. (1989) Spontaneous spiking activities of pars intermedia cells: effects of thyrotropin releasing hormone. Neuroendocrinology, 50, 33-43.

Trouslard J., Loeffler J.P., Demeneix B.A., Feltz P. Thyrotropin releasing hormone stimulates porcine melanotrope cells in primary culture. Neurosci. Letters, 1989, 98, 234-239.


Loeffler J.P., Kley N., Louis J.C., Demeneix B.A. (1988) Ca++ regulates hormone secretion and pro-opiomelanocortin gene expression in melanotrope cells via the calmodulin and the protein kinase C pathway. J. Neurochem., 52, 1279-1283.

Grant N., Demeneix B.A., Aunis D., Langley O.K. (1988) Induction of neurofilament phosphorylation in cultured chromaffin cells. Neuroscience, 27, 717-726.

Demeneix B.A., Grant N. (1988) Alpha melanocyte stimulating hormone promotes neurite outgrowth in chromaffin cells. FEBS Letters, 226, 337-342.

Loeffler J.P., Demeneix B.A., Kley N., Hollt V. (1988) Dopamine inhibition of pro-opiomelanocortin gene expression in the intermediate lobe of the pituitary: interaction with the CRF and the adrenergic receptors and the adenylate cyclase system. Neuroendocrinology, 47, 95-101.


Feltz A., Demeneix B.A., Feltz P., Taleb O., Trouslard J., Bossu J.L., Dupont J.L. (1987) Intracellular effectors and modulators of GABA A and GABA B receptors: a commentary. Biochimie, 69, 395-406.

Taleb O., Trouslard J., Demeneix B.A., Feltz P., Bossu J.L., Dupont J.L., Feltz A. (1987) Spontaneous and GABA evoked chloride channels on pituitary intermediated lobe cells and their internal Ca++ requirement. Pflugers Arch., 409, 715-730.


Taleb O., Loeffler J.P., Trouslard J., Demeneix B.A., Kley N., Hollt V., Feltz P. (1986) Ionic conductances related to GABA action on secretory and biosynthetic activity of pars intermedia cells. Brain Res. Bull., 17, 715-730.

Taleb O., Trouslard J., Demeneix B.A., Feltz P. (1986) Characterisation of sodium and calcium currents in porcine pars intermedia cells. Neurosci. Letters, 66, 55-60.

Taleb O., Demeneix B.A., Trouslard J., Feltz P. (1986) Etude électrophysiologique et biochimique des récepteurs du GABA sur une culture primaire de cellules du lobe intermédiaire du porc. Annales d’Endocrinologie, 47, 48-50.

Loeffler J.P., Demeneix B.A., Pittius C.W., Kley N., Hollt V. (1986) GABA differentially regulates the gene expression of propiomelanocortin in rat intermediate and anterior pituitary. Peptides, 7, 253-258.

Demeneix B.A., Taleb O., Loeffler J.P., Feltz P. (1986) GABA A and GABA B receptors on porcine pars intermedia cells: functional role in modulating peptide release. Neuroscience, 17, 1275-1285.


Schlichter R., Demeneix B.A., Desarmenien M., Desaulles E., Loeffler J.P., Feltz P. (1984) Properties of the GABA receptors located in spinal primary afferent neurones and hypophyseal neuroendocrine cells. Neurosci. Letters, 47, 257-263.

Demeneix B.A., Desaulles E., Loeffler J.P., Feltz P. (1984) Dual population of GABA A and GABA B receptors in rat pars intermedia demonstrated by release of MSH caused by baryum ions. Brit. J. Pharmacol., 82, 183-190.


Demeneix B.A., Lachiver F., Henderson N.E. (1983) Thyroidal iodine and thyroglobulin in hibernating and active ground squirrels Spermophilus richaredsoni. Comp. Biochem. Physiol., A75, 273-284.


Loeffler J.P., Desaulles E., Demeneix B.A., Feltz P. (1982) Electrophysiological study of GABA receptors in the rat neurointermediate lobe in vitro with K+ and Ca++ sensitive micropipettes.  Neurosci. Letters, 34, 271-276.


Henderson N.E., Demeneix B.A. (1981) Hibernation in thyroidectomised ground squirrels Spermophilus richardsoni.  Gen. Comp. Endoc., 35, 86-92.


Demeneix B.A., Henderson N.E. (1978) Mitochondrial glycerophosphate dehydrogenase in active and torpid ground squirrels Spermophilus richardsoni. Comp. Biochem. Physiol., 59B, 553-557.

Demeneix B.A., Henderson N.E. (1978) Thyroxine metabolism in active and torpid ground squirrels Spermophilus richardsoni. Gen. Comp. Endoc., 35, 86-92.

Demeneix B.A., Henderson N.E. (1978) Serum T3 and T4 in active and torpid ground squirrels, Spermophilus richardsoni. Gen. Comp. Endoc., 35, 77-85.


Tohme M., Fini J.B, Laudet V. and Demeneix B.A. (2011) Small Model Organisms as Tools in Food Safety Research. Hormone-Disruptive Chemical Contaminants in Food, RCS publishing.

Guissouma H., Dupré S.M. and Demeneix B.A. (2005) Le rétrocontrôle négatif endocrine: bases moléculaires de la régulation transcriptionnelle du gène TRH.  Medecine & Sciences.

Demeneix B.A., Hassani Z, Behr J.P. (2004) Towards multifunctional synthetic vectors. Curr Gene Ther., 4(4):445-55. Review.

Demeneix B.A. & Behr J.P. (2003) Polyfunctional vectors for gene delivery. En: Gene Therapy: Therapeutic Mechanisms and Strategies. Editor: Nancy Smyth Templeton.

Demeneix B.A., Goula D., Behr J.P. (2001) Transfert de gènes in vitro et in vivo à l’aide de lipides et de macromolécules polycationiques. En: ‘ La Thérapie Génique’. Ed. O. Cohen Haguenauer Editions TEC & DOC, Paris.

Demeneix B.A. (2000) La physiologie Comparée: Une question de Choix. En: Physiologie animale et humaine: vers une physiologie intégrative.  Rapport de l’Académie des Sciences, Editions TEC & DOC, Paris.

Demeneix B.A. (1999) Les gènes et le développement du système nerveux. En: Milles cerveaux, milles mondes. Ed. P. Buisseret,  Editions Nathan Paris.

Goula D., Lemkine G., Becker N., Normandie P., Levi G., & Demeneix B.A. (1999) Intravenous delivery of gene vectorised with polyehtylenimine: analysis of cellular mechanisms and kinetics. Proceedings of Eurocancer 99, Compte rendu du XIIème Congrès. Edité par M. Boiron & M. Marty. J. LIBBEY Eurotext.

Zou S. M., Behr J.P., Goula D. and Demeneix  B.A. Gene delivery with Polyethylenimine. (1998)  En: Gene Therapy: Therapeutic Mechanisms and Strategies. Editor: Nancy Smyth Templeton.

Demeneix B.A., Goula D., Benoist C., Rémy  J.S. and  Behr J.P. (1998) Theory and practice of using polycationic amphiphiles and polymers for in vitro and in vivo gene transfer. NATO ASI Series Gene Therapy, Ed. X. Kanthopoulos.

Remy J.-S., Goula  D. , Zanta M. A., Boussif O., Behr J.P. , Demeneix B.A. (1998) Taking lipospermines and polyethylenimine from in vitro to in vivo. En: Self-assembling systems for Gene Delivery. Seymour et al., eds, John Wiley & Sons Ltd., England.

Remy J.S., Abdallah  B. , Zanta M.A., Boussif O., Behr J.P., Demeneix. B.A. (1998) Gene transfer with lipospermines and polyethylenimines. En: Advanced Drug Delivery Reviews, Ed. P. Felgner and A. Rolland.

Ghorbel M. Guissoma, H.,  Sachs L., de Luze A., Demeneix  B.A. (1997) In vivo  Studies of T3 dependent transcription in Xenopus and Mouse. Proc. of the XIII International Congress of Comparative Endocrinology. Ed . S. Kawashima, Monduzzi Editore, Bologna.

Demeneix B.A., Boussif O., Zanta M.A., Remy J.S., Behr J.P. (1997) Delivery of polynucleotides with polyamine lipids and polymers. Nucleosides & Nucleotides, 16 (7-9), 1121-1127.

Demeneix B.A., Behr J.P. (1996) The proton sponge: a trick the viruses didn’t exploit. En: Gene therapy and Self-assembling systems for Gene transfer, Behr, Felgner, Heller, Lehn, Szoka eds, ACS Books, Washington.

Demeneix B.A., Remy J.S., Boussif O., Zanta M.A., Behr J.P. (1996) The proton sponge: taking over from the viruses. En: Molecular Diagnosis and Gene Therapy. P. Johnstone ed, Kluwer Academic Pub., Dordrecht.

Demeneix B.A., Kley N. (1989) Transdifferentiation to a neuronal phenotype in adult bovine chromaffin cells: effects of alpha-MSH. bFGF and histamine. En: The Molecular Biology of Neuroreceptors and Ion channels. Eds. A. Maelicke & H. Betz, NATO ASI series A.

Demeneix B.A., Loeffler J.P. and Feltz P. (1986) GABA-ergic mechanisms and their functional relevance in the pituitary. En: GABA-ergic mechanisms in mammalian periphery, 261-289. Eds. ERDO S.L. and BOWERY N.G., Raven Press, New-York.

Canguilhem B., Vivien-Roels B., Demeneix B.A., Miro J.L., Masson-Pevet P. (1985) Seasonal and endogenous variations of plasma testosterone (T), thyroxine (T4) and triiodothyronine (T3) in the european Hamster. En: Endocrine regulations and adaptive mechanisms to the environment. Eds. J. Boissin CNRS, Paris.

Loeffler J.P., Desaulles E., Demeneix B.A. and Feltz P. (1984) Ionic movements related to GABA action on neurosecretory fibers and endocrine cells of the hypophyseal neuro-intermediate lobe (NIL).  En: Recent Advances of Theory and Application of Ion-selective microelectrodes in Physiology and Medecine, 174-183. Eds SIMON C. and NICHOLSON, Springer International Berlin Heidelberg, New-York.

Desarmenien M., Santangelo F., Occhipinti G., Schlichter R. Loeffler J.P., Desaulles E., Demeneix B.A. and Feltz P. (1983) Electrophysiological study of GABAA versus GABAB receptors in excitation-secretion coupling. En: Adv. in biochem. Psycho-pharmac., 37, 93-105. Eds. COSTA C. and GREENGARD P., Raven Press, New-York.